Megiddo Bridge is the bridge connecting Maidenholm to Lud's Holm. The bridge has been quarantined to keep plague wastrels from crossing. Inside a doctor will overlook the player before letting them through. They will be able to pass through if they are either on Joy or Sunshine.
- The bridge name is a reference to the Battle of Megiddo in 1918 during WWI between the British Empire forces and the Ottoman Empire.
- In earlier versions of the game, the bridge was named Blenheim Bridge, named after real Old Blenheim Bridge which was used to transfer vehicles until 1932. There was also a quest at the bridge that the player would have to complete before entering Lud's Holm.
- In Act Three, plague wastrels have broken through the bridge security.